RESOURCES

UK-Biobank Single Variant Association Analysis Results

Using SAIGE, we have analyzed ~1,400 UKBiobank Phecode binary phenotypes (400,000 White British samples) on 28 million imputed variants. All analysis summary statistics are available from the following link. 

• Phenotype information table (Excel file): link

• Pheweb: link

• Summary statistics

  • ftp://share.sph.umich.edu/UKBB_SAIGE_HRC/

Note: we have moved summary statistics from Dropbox to FTP site. 

Acknowledgement: The analysis was done with collaboration with Dr. Willer and Dr. Abecasis groups. The Pheweb was created by Dr. Abecasis group.

UK-Biobank Gene-Based

Rare Variant Association Results 

Using SAIGE-GENE, we have carried out gene-based rare variant test (MAF < 0.01) for 53 UKBiobank quantitative phenotypes (400,000 White British samples). Missense and stop-gain variants were used in the analysis. The association test p-value are available from the following link.

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• Summary statistics

  • ftp://share.sph.umich.edu/UKBB_SAIGE_GENE_HRC 

UK-Biobank GxE analysis for 80 Phenotype x Environment combinations

UK-Biobank WES Binary Phenome Analysis

Using SPAGE, we have carried out GxE analysis for 80 selected phenotype x environment combinations. The association test p-value are available from the following link.

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• Summary statistics

  • ftp://share.sph.umich.edu/UKBB_SPAGE_HRC 

Using robust SKAT-O approach for binary phenotypes, we analyzed UK-Biobank WES data for 791 binary phenotypes. 

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• PheWEB-like visual server for summary statistics

  • http://ukb-50kexome.leelabsg.org/